Nightmare Dungeons

Nightmare Dungeons are another strong option. High enemy density means more elite kills, more loot drops, and more chances for unique items to appear. Completing Nightmare Dungeons also rewards end-of-run loot chests, which have an increased chance of Diablo 4 Items containing uniques.

If you're also farming Glyph experience and Masterworking materials, Nightmare Dungeons offer excellent efficiency.

World Events and World Bosses

World events such as Helltides and Gathering Legions have elevated unique drop rates compared to normal open-world farming. Among these, Helltide events are especially valuable due to their targeted loot chests.

During Helltides, focus on opening:

Tortured Gift of Jewelry: Amulet (125 Aberrant Cinders)

Tortured Gift of Mystery (250 Aberrant Cinders)

The Jewelry chest allows you to specifically target amulets, while the Mystery chest offers a higher chance at any unique item.

Gambling with Murmuring Obols

You can gamble for amulets at the Purveyor of Curiosities using Murmuring Obols. Amulets cost 100 Obols each, but this method is extremely unreliable due to the wide rarity pool. While it's possible to get Sanctis of Kethamar this way, it should be treated as a supplemental option rather than a primary farming method.

Final Thoughts

Sanctis of Kethamar is a top-tier ancestral unique amulet that perfectly complements Arbiter of Justice Paladin builds. With massive damage scaling, aura amplification, and elite-focused bonuses, it is one of the most impactful upgrades you can equip in Diablo 4.

If you're looking to optimize faster, combining efficient farming with the option to buy D4 materials can help you fully Masterwork this amulet and unlock its true endgame potential.